From Your Health Journal…..”For years, we have seen a direct correlation between obesity and type 2 diabetes. Many years ago, type 2 diabetes was known as non-insulin dependent diabetes or adult onset diabetes. Sadly, many children developed the ‘adult onset’ diabetes – kinda seemed hard to keep that name?? In most cases, type 2 diabetes is environmental, and controllable by the individual who contracted it. A healthy diet and exercise may be enough to end it for many, for others, not so lucky. So, when this breakthrough in the mice in this study came through, many were happy to read that ‘blocking the body’s inflammation response to high-fat foods’ may help lower the risks of type 2 diabetes. The study saw the results in mice, but they are not sure about how it may effect humans. But….promising to read.

From the article…..

Researchers hope to cut the connection between fatty diet and insulin resistance, but it’s complicated

Obesity and type 2 diabetes are clearly intertwined, but researchers say they’ve found a way to weaken the connection between the two — at least in mice.

The key, they say, is blocking the body’s inflammation response to high-fat foods.

In this study, published online Dec. 6 in the journal Science, the researchers turned off the JNK (pronounced “junk”) genetic pathway in mice, and fed the rodents high-fat diets. Even though the mice became obese, they didn’t develop insulin resistance, a forerunner to diabetes.

Other similarly stuffed mice with intact JNK pathways, however, became insulin resistant.

Although the results look promising, it’s too early to say whether the findings might apply to humans.

“Everybody has these genes, and they’re present within all cells of your body all the time,” said study author Roger Davis. “What they do is respond to the diet that you’re eating. So if you eat a high-fat, cafeteria diet, it leads to the activation of the protein products — the enzymes — of these genes.”

Davis, a professor at the University of Massachusetts Medical School and investigator at the Howard Hughes Medical Institute in Worcester, Mass., and his colleagues studied hundreds of mice over multiple years to examine the relationship between inflammation and diabetes.

“What we discovered is the JNK genes in the macrophages are critical for the ability of macrophages to cause inflammation, specifically in response to feeding or eating a high-fat diet,” Davis said.

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