Type 1 Diabetes New Staging System Promotes Early Detection

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diabeteswordThis article was submitted by the Baylor College of Medicine, please share your comments below…..

For most people with type 1 diabetes, the disease seems to occur suddenly, often resulting in a trip to the emergency room with life-threatening complications. But a new recommendation calls for a diabetes staging classification that could mean earlier diagnosis and better outcomes for patients in the long run.

The recommendation was made by the JDRF, the American Diabetes Association and the Endocrine Society in the January issue of the journal Diabetes Care and is based on research from TrialNet, an NIH-funded international network of research centers, including Baylor College of Medicine and Texas Children’s Hospital.

The research indicates that type 1 diabetes can now be most accurately understood as a disease that progresses in three distinct stages.

Stage 1 is the start of type 1 diabetes. Individuals test positive for two or more diabetes-related autoantibodies. The immune system has already begun attacking the insulin-producing beta cells, although there are no symptoms and blood sugar remains normal.

Stage 2, like stage 1, includes individuals who have two or more diabetes-related autoantibodies, but now, blood sugar levels have become abnormal due to increasing loss of beta cells. There are still no symptoms.

For both stages 1 and 2, lifetime risk of developing type 1 diabetes approaches 100 percent.

Stage 3 is when clinical diagnosis has typically taken place. By this time, there is significant beta cell loss and individuals generally show common symptoms of type 1 diabetes, which include frequent urination, excessive thirst, weight loss and fatigue.

“Clinical research supports the usefulness of diagnosing type 1 diabetes early – before beta cell loss advances to stage 3. The earlier diagnosis is made in the disease process, the sooner intervention can take place, and the more beta cells are likely to remain. More beta cells may lead to better outcomes regarding blood sugar control and reduction of long-term complications,” said. Dr. Maria Redondo, director of the Texas Children’s/Baylor TrialNet Clinical Center and associate professor of pediatrics at Baylor and in the diabetes and endocrinology section at Texas Children’s Hospital.

The Texas Children’s/Baylor TrialNet Program serves as one of the 14 TrialNet Clinical Centers throughout the United States, Europe, Canada and Australia. TrialNet was founded in 2001 and since then has screened approximately 150,000 participants for type 1 diabetes markers.

Screening is recommended for people who have relatives with type 1 diabetes. Family members have a 15 times greater risk of being diagnosed than a person with no family history. TrialNet screening is available at no charge to:

* Anyone between the ages of 1 and 45 with a sibling, child or parent with type 1 diabetes.

* Anyone between the ages of 1 and 20 with a sibling, child, parent, cousin, uncle, aunt, niece, nephew, grandparent or half-sibling with type 1 diabetes.

“TrialNet’s goal is to identify the disease at its earliest stage, delay progression and ultimately prevent it. We offer screening and clinical trials for every stage of type 1 diabetes and close monitoring for disease progression,” Redondo said.

For people who participate in type 1 diabetes prevention research like TrialNet, the risk of diabetic ketoacidosis (DKA) at diagnosis decreases to less than 4 percent from 30 percent. DKA is a serious complication of diabetes than can lead to coma or even death.

For more information or to participate, call 832-824-1207 or email TrialNet@texaschildrens.org.

Woodloch Pines Resort And JDRF Team Up In The Fight Against Type 1 Diabetes

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Woodloch will host its second annual “Carnival for a Cause” to raise money for JDRF

diabeteswordWoodloch Pines Resort has partnered with JDRF, the only global organization with a strategic plan to end Type 1 Diabetes (T1D), with the ultimate goal to turn Type One into Type None.

During the weekend of May 1st – 3rd, 2015, the social activities department from Woodloch Pines, an all-inclusive family resort in Pennsylvania’s Pocono Mountains, will host its famous home-grown carnival. Deemed “Carnival for a Cause,” a portion of all proceeds raised during the weekend will go directly to JDRF. This is the second year in which the resort is supporting the cause. In 2014, resort guests, staff, and local friends raised over $15,000 in donations. Since the family resort’s opening back in 1958, Woodloch’s Carnival has been a beloved activity enjoyed every summer by many guests.

Woodloch Pines shares a special personal connection with JDRF’s mission to bring awareness to Type 1 Diabetes (T1D) in hopes of one day finding a cure for the disease. The Pocono resort’s longtime Social Director, Joey Ranner, has a granddaughter who was diagnosed with T1D in November of 2011. Type 1 Diabetes is an autoimmune disease in which a person’s pancreas stops producing insulin, a hormone people need to get energy from food. T1D strikes both children and adults and lasts a lifetime. The disease can have devastating effects such as: kidney failure, blindness, nerve damage, heart attack, stroke, and pregnancy complications.

“Seeing how Type 1 Diabetes affects young children, like my granddaughter Jillian, makes me want to do something to help. One of the best resources that our family found after Jillian’s diagnosis was JDRF. We’ve participated in JDRF’s ‘Walk to Cure Diabetes’ for the past four years to help raise money to aid the admirable efforts of this great organization,” says Ranner. “Since Woodloch is and always has been about putting family first and giving back to the community, partnering with JDRF is a natural fit.”

The all-inclusive family resort’s “Carnival for a Cause” will embody a carnival’s midway atmosphere. At the event, which will take place on Saturday, May 2nd, guests can play the unique games for a chance to win prizes, including the grand prize of an all-inclusive getaway to the Pocono resort. Alongside the midway games, guests will be entertained by a balloon artist, magician, live music, food vendors, and inflatable bounce houses (weather permitting).

In addition to the carnival, other special events for the weekend include:

– A live cooking class featuring tasty yet healthy low sugar options

– A “Dance-A-Thon” where Woodloch Staff and guests will join together to dance the night away in order to raise donations

– A benefit 9-hole shotgun golf tournament at The County Club at Woodloch Springs

diabetesword– The East Central PA branch of JDRF will also be hosting their annual “Walk to Cure” event at PNC Field in Moosic on May 3rd. Registration information is available at EastCentralPA.jdrf.org.

During Carnival for a Cause weekend, all-inclusive rates start at just $199 per adult per night. For more information or to book a stay during, please visit http://www.woodloch.com/jdrf or call 1.800.WOODLOCH.

About JDRF:

JDRF is the only global organization with a strategic research plan to end type 1 diabetes (T1D). The plan ensures that there will be an ongoing stream of life-changing therapies moving from development through to the marketplace that lessen the impact of T1D keeping people with T1D healthy and safe today until the ultimate goal of a cure and universal prevention of T1D, turning Type One into Type None. Since its founding in 1970, JDRF’s cumulative research funding totals over $1.8 billion. In 2013 alone, JDRF’s T1D research funding totaled more than $106 million. More than 80 percent of JDRF’s expenditures directly support research and research-related education.

About Woodloch Pines Resort:

Creating a magical experience for families since 1958, Woodloch Pines Resort’s signature warm hospitality keeps guests returning year after year and offers a truly unique all-inclusive family vacation experience fitting for everyone’s taste. An award-winning family resort, championship golf course and sister property featuring a luxury destination spa are just 95 scenic and convenient miles from New York City nestled in the Pocono Mountains Lake Region.

Contact:
Erica Filstein
Office: 570.685.8072 or Erica.Filstein@woodloch.com

Type 1 Diabetes Rate Among Young Children Grew 70 Percent Over 2 Decades

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diabeticFrom Your Health Journal…..”So much as been in the news regarding the rise of obesity in children, and how so many children have been diagnosed with type 2 diabetes, formally known as adult onset diabetes – since it was visible mostly in adults. There is a strong correlation between type 2 diabetes and obesity. Ninety-five percent of diagnosed diabetes is usually type 2. Today, I found a great story from On Central, a Southern California Public Radio station. The article was written by José Martinez entitled, Type 1 Diabetes Rate Among Young Children Grew 70 Percent Over 2 Decades. Type 1 diabetes is what happens when little to no insulin is produced, as the pancreas stops creating it. Insulin is what is needed to deliver glucose (energy) through the cells of the body. Experts still aren’t sure what causes it, although it’s most often diagnosed in children, teenagers or young adults – it used to be called juvenile diabetes. But now, research is suggesting that type 1 diabetes is on the rise among children. So, it will be interesting to see further research into this matter. Please visit the On Central web site (link provided below) to read the complete article.”

From the article…..

Local health care providers say type 2 diabetes is way more prevalent than the type 1 variety in South Los Angeles – that’s true for both adults and children.

In fact, that seems to be true across the board: Up to 95 percent of all diagnosed diabetes cases are type 2.

Obesity is the primary risk factor for type 2 diabetes, which can develop when the body becomes resistant to insulin. Genetics also play a role in a person’s development of the disease.

Type 1, on the other hand, is what happens when little to no insulin is produced. Experts still aren’t sure what causes it, although it’s most often diagnosed in children, teenagers or young adults.

With child obesity on the rise, doctors knew that rising rates of type 2 diabetes among youngsters would be close behind. That problem is especially acute in South L.A., where the rates of child obesity are among the county’s highest. The trend is so worrisome that the American Academy of Pediatrics recently released the first official guidelines – ever – regarding how to treat the disease in children.

But now researchers on the East Coast are seeing a similar pattern with type 1 diabetes among children: A new study appearing in Diabetes Care found that incidence of the disease in very young children from Philadephia – those under the age of five – increased by a whopping 70 percent between 1985 and 2004.

To read the complete article…..Click here

Type 1 Diabetes Cured In Dogs

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diabetesglucoseExciting news has been published this week by Diabetes, the most important journal on the disease. Researchers from the Universitat Autonomica de Barcelona (UAB) have shown for the first time that it is possible to cure Type 1 Diabetes in large animals with gene therapy. Two diabetic dogs were treated with a single session of gene therapy, and completely recovered their health and no longer show any signs of the disease.

Gene therapy is a new way of treating disease that uses DNA as a pharmaceutical agent. An injection of modified genes are injected into the patient, and the DNA modifies or supplements the patient’s genes so as to better fight off any given disease. Gene therapy can be used to encode a functional gene that helps a cell fight off disease, correct mutations, or create a therapeutic protein drug.

The researchers at UAB led by Fatima Bosch achieved their results with only one round of injections to the dog’s rear legs. These injections introduced gene therapy vectors that accomplished two things: they expressed an insulin gene, and they activated glucokinase. Glucokinase is an enzyme that controls how much glucose is taken out of the blood stream, and when both of these new genes act together, they work as a ‘glucose detector’, which helps control the glucose levels in the blood and thus reducing hypoglycemia.

diabeteswordThe dogs were treated over four years ago, and since that single round of treatments have shown consistently better health than other dogs that were given frequent insulin shots to help control their diabetes. They showed good glucose levels at all times, even after meals or during fasts, and improved their weight and developed no secondary complications.

This is the first study to be successfully run on a large mammal, though excellent results were achieved before with mice. The success that the UAB team has achieved with dogs opens the doors to developing gene therapy techniques for veterinary medicine, and eventually into treating diabetic human patients. This revolutionary achievement opens high expectations that gene therapy may prove to be the best solution to our burgeoning diabetes crisis, and the fact that only one session was needed also speaks to both the efficacy of the treatment and its permanent benefits.

Phil Tucker is a health and fitness blogger. He’s looking to feel younger as he gets older – check out his webpage to learn more, or read his blog!